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Article

Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.

Journal of lipid research - 1 Nov 2010

Guella Ilaria, Asselta Rosanna, Ardissino Diego, Merlini Pier Angelica, Peyvandi Flora, Kathiresan Sekar, Mannucci Pier Mannuccio, Tubaro Marco, Duga Stefano

Abstract excerpt

The R46L variant in the proprotein-convertase subtilisin-kexin type 9 (PCSK9) gene was associated with reduced levels of LDL and total cholesterol and with a lower risk of coronary artery disease. We investigated the association of R46L with myocardial infarction (MI) in 1,880 Italian patients with premature MI and 1,880 controls. A trend toward a protective effect of the L46 allele was observed [odds ratio (OR)...

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Source

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Identifiers

PMID: 20699424
DOI: 10.1194/jlr.M010009
PMCID: PMC2952575

Genes

PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Effects of PCSK9 genetic variants on plasma LDL cholesterol levels and risk of premature myocardial infarction in the Italian population.PMID 20699424Read ↗

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