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Article

AID/APOBEC-like cytidine deaminases are ancient innate immune mediators in invertebrates.

Nature communications - 16 May 2018

Liu Mei-Chen, Liao Wen-Yun, Buckley Katherine M, Yang Shu Yuan, Rast Jonathan P, Fugmann Sebastian D

Abstract excerpt

In the course of both innate and adaptive immunity, cytidine deaminases within the activation induced cytidine deaminase (AID)/apolipoprotein B editing complex (APOBEC) family modulate immune responses by mutating specific nucleic acid sequences of hosts and pathogens. The evolutionary emergence of these mediators, however, seems to coincide precisely with the emergence of adaptive immunity in vertebrates. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29769532
DOI: 10.1038/s41467-018-04273-x
PMCID: PMC5956068

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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