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Article

Biochemical Regulatory Features of Activation-Induced Cytidine Deaminase Remain Conserved from Lampreys to Humans.

Molecular and cellular biology - 15 Oct 2017

Quinlan Emma M, King Justin J, Amemiya Chris T, Hsu Ellen, Larijani Mani

Abstract excerpt

Activation-induced cytidine deaminase (AID) is a genome-mutating enzyme that initiates class switch recombination and somatic hypermutation of antibodies in jawed vertebrates. We previously described the biochemical properties of human AID and found that it is an unusual enzyme in that it exhibits binding affinities for its substrate DNA and catalytic rates several orders of magnitude higher and lower,...

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Identifiers

PMID: 28716949
DOI: 10.1128/MCB.00077-17
PMCID: PMC5615186

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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