Article
CD109 deficiency induces osteopenia with an osteoporosis-like phenotype in vivo.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Jul 2018
Mii Shinji, Hoshino Akiyoshi, Enomoto Atsushi, Murakumo Yoshiki, Ito Masako, Yamaguchi Akira, Takahashi Masahide
Abstract excerpt
Osteoporosis is a global public health problem that is increasing along with an aging population. A major determinant of osteoporosis is high bone turnover, which results from osteoclast activation. CD109 is a glycosylphosphatidylinositol-anchored glycoprotein, a deficiency that leads to a psoriasis-like skin inflammation in mice. Although the expression of CD109 has been reported in mouse pre-osteoclast cells,...
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