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Article

Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw.

Calcified tissue international - 1 Dec 2012

Zhao Yinghua, Wang Lei, Liu Yi, Akiyama Kentaro, Chen Chider, Atsuta Ikiru, Zhou Tao, Duan Xiaohong, Jin Yan, Shi Songtao

Abstract excerpt

Technetium-99 conjugated with methylene diphosphonate ((99)Tc-MDP) is a novel bisphosphonate derivative without radioactivity and has been successfully used to treat arthritis in China for years. Since bisphosphonate therapy has the potential to induce bisphosphonate-related osteonecrosis of the jaw (BRONJ), we examined whether (99)Tc-MDP represents a new class of bisphosphonate for antiresorptive therapy to...

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Identifiers

PMID: 23064899
DOI: 10.1007/s00223-012-9649-7
PMCID: PMC3850783

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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