Article
GMF severs actin-Arp2/3 complex branch junctions by a cofilin-like mechanism.
Current biology : CB - 17 Jun 2013
Ydenberg Casey A, Padrick Shae B, Sweeney Meredith O, Gandhi Meghal, Sokolova Olga, Goode Bruce L
Abstract excerpt
BACKGROUND: Branched actin filament networks driving cell motility, endocytosis, and intracellular transport are assembled in seconds by the Arp2/3 complex and must be equally rapidly debranched and turned over. One of the only factors known to promote debranching of actin networks is the yeast homolog of glia maturation factor (GMF), which is structurally related to the actin filament-severing protein cofilin....
Topics
- Actin Cytoskeleton
- Actin-Related Protein 2-3 Complex
- Alleles
- Amino Acid Sequence
- Animals
- Binding Sites
- Cofilin 1
- Glia Maturation Factor
- Mice
- Molecular Sequence Data
- Mutation