Article
Rare genetic variants explain missing heritability in smoking.
Nature human behaviour - 1 Nov 2022
Jang Seon-Kyeong, Evans Luke, Fialkowski Allison, Arnett Donna K, Ashley-Koch Allison E, Barnes Kathleen C, Becker Diane M, Bis Joshua C, Blangero John, Bleecker Eugene R, Boorgula Meher Preethi, Bowden Donald W, Brody Jennifer A, Cade Brian E, Jenkins Brenda W Campbell, Carson April P, Chavan Sameer, Cupples L Adrienne, Custer Brian, Damrauer Scott M, David Sean P, de Andrade Mariza, Dinardo Carla L, Fingerlin Tasha E, Fornage Myriam, Freedman Barry I, Garrett Melanie E, Gharib Sina A, Glahn David C, Haessler Jeffrey, Heckbert Susan R, Hokanson John E, Hou Lifang, Hwang Shih-Jen, Hyman Matthew C, Judy Renae, Justice Anne E, Kaplan Robert C, Kardia Sharon L R, Kelly Shannon, Kim Wonji, Kooperberg Charles, Levy Daniel, Lloyd-Jones Donald M, Loos Ruth J F, Manichaikul Ani W, Gladwin Mark T, Martin Lisa Warsinger, Nouraie Mehdi, Melander Olle, Meyers Deborah A, Montgomery Courtney G, North Kari E, Oelsner Elizabeth C, Palmer Nicholette D, Payton Marinelle, Peljto Anna L, Peyser Patricia A, Preuss Michael, Psaty Bruce M, Qiao Dandi, Rader Daniel J, Rafaels Nicholas, Redline Susan, Reed Robert M, Reiner Alexander P, Rich Stephen S, Rotter Jerome I, Schwartz David A, Shadyab Aladdin H, Silverman Edwin K, Smith Nicholas L, Smith J Gustav, Smith Albert V, Smith Jennifer A, Tang Weihong, Taylor Kent D, Telen Marilyn J, Vasan Ramachandran S, Gordeuk Victor R, Wang Zhe, Wiggins Kerri L, Yanek Lisa R, Yang Ivana V, Young Kendra A, Young Kristin L, Zhang Yingze, Liu Dajiang J, Keller Matthew C, Vrieze Scott
Abstract excerpt
Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use with whole-genome sequences from up to 26,257 unrelated individuals of European ancestries and 11,743 individuals of African ancestries. Across four smoking traits,...
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