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Article

Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias.

Journal of medical genetics - 1 Feb 2003

Reid E

Abstract excerpt

The hereditary spastic paraplegias are a group of neurodegenerative conditions that all share the principal clinical feature of progressive lower limb spastic paralysis, caused by either failure of development or progressive degeneration of the corticospinal tract. The conditions are characterised by extreme genetic heterogeneity, with at least 20 genes involved. Until recently, no functional overlap was apparent...

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Source

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Identifiers

PMID: 12566514
DOI: 10.1136/jmg.40.2.81
PMCID: PMC1735361

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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