Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome.

Molecular biology reports - 1 Aug 2018

Vitorino Marta, Cunha Nídia, Conceição Natércia, Cancela M Leonor

Abstract excerpt

Atypical Rett syndrome is a child neurodevelopmental disorder induced by mutations in CDKL5 gene and characterized by a progressive regression in development with loss of purposeful use of the hands, slowed brain and head growth, problems with walking, seizures, and intellectual disability. At the moment, there is no cure for this pathology and little information is available concerning animal models capable of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Epileptic Syndromes
Share to In Situ Hybridization

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Protein Serine-Threonine Kinases

Share to Sequence Alignment

Share to Sequence Homology, Amino Acid

Share to Spasms, Infantile

Share to Zebrafish

Source

Identifiers

PMID: 29752575
DOI: 10.1007/s11033-018-4180-1

Genes

CDKL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression pattern of cdkl5 during zebrafish early development: implications for use as model for atypical Rett syndrome.PMID 29752575Read ↗

Transcriptomic Profiling of Zebrafish Mutant for cdkl5 Reveals Dysregulated Gene Expression Associated with Neuronal, Muscle, Visual and Skeletal DevelopmentSemantic proximity Read ↗

Novel pre-clinical model for CDKL5 Deficiency DisorderSemantic proximity Read ↗

CDKL5/Stk9 kinase inactivation is associated with neuronal developmental disorders.Semantic proximity Read ↗

Autistic-relevant behavioral phenotypes of a mouse model of cyclin-dependent kinase-like 5 deficiency disorder.Semantic proximity Read ↗

Zebrafish knockout of frk gene shows social impairments relevant to autism and delays brain development by increasing cell proliferationSemantic proximity Read ↗

Cyclin-Dependent Kinase-Like 5 (CDKL5): Possible Cellular Signalling Targets and Involvement in CDKL5 Deficiency Disorder.Semantic proximity Read ↗

Novel CDKL5 Mutations in Czech Patients with Phenotypes of Atypical Rett Syndrome and Early-Onset Epileptic Encephalopathy.Semantic proximity Read ↗

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.Semantic proximity Read ↗

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.Semantic proximity Read ↗

A novel mutation in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene associated with a severe Rett phenotype.Semantic proximity Read ↗

Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.Semantic proximity Read ↗

p35 and p39 are essential for cyclin-dependent kinase 5 function during neurodevelopment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.