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Article

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.

Human molecular genetics - 15 Sept 2016

Trazzi Stefania, Fuchs Claudia, Viggiano Rocchina, De Franceschi Marianna, Valli Emanuele, Jedynak Paulina, Hansen Finn K, Perini Giovanni, Rimondini Roberto, Kurz Thomas, Bartesaghi Renata, Ciani Elisabetta

Abstract excerpt

Cyclin-dependent kinase-like 5 (CDKL5) is a Ser/Thr protein kinase predominantly expressed in the brain. Mutations of the CDKL5 gene lead to CDKL5 disorder, a neurodevelopmental pathology that shares several features with Rett Syndrome and is characterized by severe intellectual disability. The phosphorylation targets of CDKL5 are largely unknown, which hampers the discovery of therapeutic strategies for...

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Source

Identifiers

PMID: 27466189
DOI: 10.1093/hmg/ddw231

Genes

CDKL5
HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder.PMID 27466189Read ↗

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