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Article

DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1

11 May 2018

Abstract excerpt

Cancer stem cells (CSCs), representing the root of many solid tumors including ovarian cancer, have been implicated in disease recurrence, metastasis, and therapeutic resistance. Our previous study has demonstrated that the CSC subpopulation in ovarian cancer can be limited by DNA damage-binding protein 2 (DDB2). Here, we demonstrated that the ovarian CSC subpopulation can be maintained via cancer cell...

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PMID: 29752431
DOI: 10.1038/s41419-018-0585-y

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