Article

Suppression of hypoxia-induced stemness and chemoresistance in ovarian tumors

2023-12-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Hypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on the presence of cancer stem cells (CSCs), and hypoxia promotes their generation through transcriptional activation by HIF transcription factors. <bold>Methods.</bold> We used OC cell lines, xenograft models, OC patient sampl...

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Literature Corpus work: 1246396f-25c8-5435-bfd0-27021343a781
DOI: 10.21203/rs.3.rs-3730407/v1

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