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FOXK2 promotes ovarian cancer stemness by regulating the unfolded protein response pathway

29 Mar 2022

Abstract excerpt

Understanding the regulatory programs enabling cancer stem cells (CSCs) to self-renew and drive tumorigenicity could identify new treatments. Through comparative chromatin-state and gene expression analyses in ovarian CSCs versus non-CSCs, we identified FOXK2 as a highly expressed stemness-specific transcription factor in ovarian cancer. Its genetic depletion diminished stemness features and reduced tumor...

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PMID: 35349489
DOI: 10.1172/jci151591

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