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BRCA1 and EZH2 cooperate in regulation of prostate cancer stem cell phenotype

10 Apr 2019

Abstract excerpt

Prostate cancer (PCa) is the second most common malignancy and the sixth leading cause of cancer-related death among men worldwide. Prostate carcinogenesis is driven by the accumulation of genetic and epigenetic aberrations, which regulate cancer cell transition between a stem- and nonstem-cell state and accelerate tumor evolution. Elevated expression of enhancer of zeste homolog 2 (EZH2) histone...

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PMID: 30968962
DOI: 10.1002/ijc.32323

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