Article

Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors

2023-07-19

Abstract excerpt

<h4>Summary</h4> Hypoxia in solid tumors is a source of chemoresistance that determines poor patient prognosis and relies on the presence of cancer stem cells (CSCs). Here we use ovarian cancer (OC) as a model and a combination of 2D and 3D cell cultures, xenograft models, patient samples, transcriptional databases, iPSCs and ATAC-seq, to address the mechanisms leading to hypoxia-induced CSC generation and chemor...

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Literature Corpus work: fa31e431-b552-5b30-a2d7-fe295db4e8dc
DOI: 10.1101/2023.07.19.549738

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