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Article

DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1.

Oncogene - 21 May 2015

Yun E-J, Baek S T, Xie D, Tseng S-F, Dobin T, Hernandez E, Zhou J, Zhang L, Yang J, Sun H, Xiao G, He D, Kittler R, Hsieh J-T

Abstract excerpt

Cancer stem cell (CSC), the primary source of cancer-initiating population, is involved in cancer recurrence and drug-resistant phenotypes. This study demonstrates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many cancer types, is associated with CSC properties. Mechanistically, DAB2IP is able to suppress stem cell factor receptor (c-kit or CD117) gene expression by...

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Share to GTPase-Activating Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Stem Cells

Share to Proto-Oncogene Proteins c-kit

Share to Proto-Oncogene Proteins c-myc

Share to ras GTPase-Activating Proteins

Share to TOR Serine-Threonine Kinases

Share to Zinc Finger E-box-Binding Homeobox 1

Source

Identifiers

PMID: 25043300
DOI: 10.1038/onc.2014.215

Genes

ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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