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Article

Essential role of PLD2 in hypoxia-induced stemness and therapy resistance in ovarian tumors

25 Feb 2024

Abstract excerpt

BACKGROUND: Hypoxia in solid tumors is an important source of chemoresistance that can determine poor patient prognosis. Such chemoresistance relies on the presence of cancer stem cells (CSCs), and hypoxia promotes their generation through transcriptional activation by HIF transcription factors. METHODS: We used ovarian cancer (OC) cell lines, xenograft models, OC patient samples, transcriptional databases,...

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PMID: 38403587
DOI: 10.1186/s13046-024-02988-y

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