Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2009

Tong Amy, Lynn Grace, Ngo Vy, Wong Daniel, Moseley Sarah L, Ewbank Jonathan J, Goncharov Alexandr, Wu Yi-Chun, Pujol Nathalie, Chisholm Andrew D

Abstract excerpt

Wounding of epidermal layers triggers multiple coordinated responses to damage. We show here that the Caenorhabditis elegans ortholog of the tumor suppressor death-associated protein kinase, dapk-1, acts as a previously undescribed negative regulator of barrier repair and innate immune responses to wounding. Loss of DAPK-1 function results in constitutive formation of scar-like structures in the cuticle, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis Regulatory Proteins
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium-Calmodulin-Dependent Protein Kinases

Share to Death-Associated Protein Kinases

Share to Immunity, Innate

Share to Microscopy, Electron

Share to Mutation

Share to Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 19164535
DOI: 10.1073/pnas.0809339106
PMCID: PMC2629440

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Negative regulation of Caenorhabditis elegans epidermal damage responses by death-associated protein kinase.PMID 19164535Read ↗

The defense response of Caenorhabditis elegans to Cutibacterium acnes SK137 via the TIR-1-p38 MAPK signaling pathway.Semantic proximity Read ↗

A pals-25 gain-of-function allele triggers systemic resistance against natural pathogens of C. elegans.Semantic proximity Read ↗

The <i>Drosophila</i> Inhibitor of Apoptosis Protein DIAP2 Functions in Innate Immunity and Is Essential To Resist Gram-Negative Bacterial InfectionSemantic proximity Read ↗

Mechanisms of systemic wound response in Drosophila.Semantic proximity Read ↗

Inhibitor of Apoptosis Proteins (IAPs) Limit RIPK1-Mediated Skin Inflammation.Semantic proximity Read ↗

Structural and physiological functions of Caenorhabditis elegans epidermisSemantic proximity Read ↗

Cellular and genetic analysis of wound healing in Drosophila larvae.Semantic proximity Read ↗

Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila.Semantic proximity Read ↗

Death-Associated Protein Kinase 1 Dampens Keratinocyte Necroptosis and Expression of Inflammatory Genes in Lichen PlanusSemantic proximity Read ↗

PKA/KIN-1 mediates innate immune responses to bacterial pathogens in Caenorhabditis elegansSemantic proximity Read ↗

A cullin-RING ubiquitin ligase promotes thermotolerance as part of the intracellular pathogen response in Caenorhabditis elegansSemantic proximity Read ↗

Homeostatic epithelial renewal in the gut is required for dampening a fatal systemic wound response in Drosophila.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.