Article
HIV latency reversing agents act through Tat post translational modifications.
Retrovirology - 11 May 2018
Khoury Georges, Mota Talia M, Li Shuang, Tumpach Carolin, Lee Michelle Y, Jacobson Jonathan, Harty Leigh, Anderson Jenny L, Lewin Sharon R, Purcell Damian F J
Abstract excerpt
BACKGROUND: Different classes of latency reversing agents (LRAs) are being evaluated to measure their effects in reactivating HIV replication from latently infected cells. A limited number of studies have demonstrated additive effects of LRAs with the viral protein Tat in initiating transcription, but less is known about how LRAs interact with Tat, particularly through basic residues that may be...
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