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HIV-1 transcription and latency: an update

26 Jun 2013

Abstract excerpt

Combination antiretroviral therapy, despite being potent and life-prolonging, is not curative and does not eradicate HIV-1 infection since interruption of treatment inevitably results in a rapid rebound of viremia. Reactivation of latently infected cells harboring transcriptionally silent but replication-competent proviruses is a potential source of persistent residual viremia in cART-treated patients. Although...

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PMID: 23803414
DOI: 10.1186/1742-4690-10-67

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