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Article

Engineering a vitamin B12 high-throughput screening system by riboswitch sensor in Sinorhizobium meliloti.

BMC biotechnology - 11 May 2018

Cai Yingying, Xia Miaomiao, Dong Huina, Qian Yuan, Zhang Tongcun, Zhu Beiwei, Wu Jinchuan, Zhang Dawei

Abstract excerpt

BACKGROUND: As a very important coenzyme in the cell metabolism, Vitamin B12 (cobalamin, VB12) has been widely used in food and medicine fields. The complete biosynthesis of VB12 requires approximately 30 genes, but overexpression of these genes did not result in expected increase of VB12 production. High-yield VB12-producing strains are usually obtained by mutagenesis treatments, thus developing an efficient...

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Identifiers

PMID: 29751749
DOI: 10.1186/s12896-018-0441-2
PMCID: PMC5948670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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