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Article

Beyond rational-biosensor-guided isolation of 100 independently evolved bacterial strain variants and comparative analysis of their genomes.

BMC biology - 4 Sept 2023

Baumann Philipp T, Dal Molin Michael, Aring Hannah, Krumbach Karin, Müller Moritz-Fabian, Vroling Bas, van Summeren-Wesenhagen Philana V, Noack Stephan, Marienhagen Jan

Abstract excerpt

BACKGROUND: In contrast to modern rational metabolic engineering, classical strain development strongly relies on random mutagenesis and screening for the desired production phenotype. Nowadays, with the availability of biosensor-based FACS screening strategies, these random approaches are coming back into fashion. In this study, we employ this technology in combination with comparative genome analyses to...

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PMID: 37667306
DOI: 10.1186/s12915-023-01688-x
PMCID: PMC10478468

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