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Article

Dual Selective Pressure and Intelligent Screening of Mutagenized Bacillus subtilis for Enhanced Riboflavin Production.

Journal of agricultural and food chemistry - 29 Jul 2026

Zhang Fangyu, Du Guangqing, Xia Miaomiao, Ding Dongqin, Ji Zhengzi, Yang Ziyu, Yang Junlin, Wang Yufeng, Cheng Cuigai, Gong Dachun, Zhang Dawei

Abstract excerpt

Riboflavin is an essential nutrient widely used in food, feed, and pharmaceutical industries, yet efficient screening of high-yield microbial strains remains a major bottleneck in industrial production. Here, we developed an integrated strategy combining dual selective pressure, optimized microplate fermentation, and stepwise high-throughput screening to accelerate the isolation of riboflavin-overproducing...

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PMID: 42464686
DOI: 10.1021/acs.jafc.5c13930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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