Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High-Level 5-Methyltetrahydrofolate Bioproduction in Bacillus subtilis by Combining Modular Engineering and Transcriptomics-Guided Global Metabolic Regulation

6 May 2022

Abstract excerpt

5-Methyltetrahydrofolate (5-MTHF) is the predominant folate form in human plasma, which has been widely used as a nutraceutical. However, the microbial synthesis of 5-MTHF is currently inefficient, limiting green and sustainable 5-MTHF production. In this study, the Generally Regarded As Safe (GRAS) microorganism Bacillus subtilis was engineered as the 5-MTHF production host. Three precursor supply modules were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Enzymes and Metabolism
Share to Folate and B Vitamins Research
Share to Metabolism and Genetic Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35521920
DOI: 10.1021/acs.jafc.2c01252

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High-Level 5-Methyltetrahydrofolate Bioproduction in Bacillus subtilis by Combining Modular Engineering and Transcriptomics-Guided Global Metabolic RegulationPMID 35521920Read ↗

Systems metabolic engineering of Bacillus subtilis for efficient biosynthesis of 5‐methyltetrahydrofolateSemantic proximity Read ↗

Deregulation of purine pathway in Bacillus subtilis and its use in riboflavin biosynthesis.Semantic proximity Read ↗

Engineering of Bacillus subtilis for enhanced total synthesis of folic acid.Semantic proximity Read ↗

Engineering a vitamin B12 high-throughput screening system by riboswitch sensor in Sinorhizobium meliloti.Semantic proximity Read ↗

Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa DrugsSemantic proximity Read ↗

Progress in the microbial production of S-adenosyl-L-methionine.Semantic proximity Read ↗

Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of actionSemantic proximity Read ↗

Accumulation of gene-targeted Bacillus subtilis mutations that enhance fermentative inosine production.Semantic proximity Read ↗

The methionine salvage pathway in Bacillus subtilis.Semantic proximity Read ↗

Dihydrofolate Reductase/Thymidylate Synthase Fine-Tunes the Folate Status and Controls Redox Homeostasis in Plants.Semantic proximity Read ↗

Thiamine pyrophosphate riboswitches in <i>Bacteroides</i> species regulate transcription or translation of thiamine transport and biosynthesis genesSemantic proximity Read ↗

Enzymatic regulation of methionine/homocysteine levels by the folate pathway dictates broad-spectrum defense in Arabidopsis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.