Hypothesis: the rs66698963 insertion-deletion alters the AA/EPA ratio and cardiovascular disease risk.

doi:10.1186/s12944-026-02917-2

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Hypothesis: the rs66698963 insertion-deletion alters the AA/EPA ratio and cardiovascular disease risk.

Lipids in health and disease - 17 Mar 2026

Oliveira Igor, Gilpin-Falk Andreas Elias, Block Robert C

Abstract excerpt

Cardiovascular disease (CVD) remains the leading cause of mortality worldwide. In addition to established risk factors such as hypertension, dyslipidemia and smoking, genetic variations may modulate individual susceptibility to CVD. The rs66698963 insertion–deletion (indel) polymorphism in the fatty‑acid desaturase (FADS) gene cluster increases fatty‑acid desaturase 1 activity and elevates circulating arachidonic...

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PMID: 41840646
DOI: 10.1186/s12944-026-02917-2
PMCID: PMC13107612

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