Article
Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid.
Molecular biology and evolution - 1 Jul 2016
Kothapalli Kumar S D, Ye Kaixiong, Gadgil Maithili S, Carlson Susan E, O'Brien Kimberly O, Zhang Ji Yao, Park Hui Gyu, Ojukwu Kinsley, Zou James, Hyon Stephanie S, Joshi Kalpana S, Gu Zhenglong, Keinan Alon, Brenna J Thomas
Abstract excerpt
Long chain polyunsaturated fatty acids (LCPUFA) are bioactive components of membrane phospholipids and serve as substrates for signaling molecules. LCPUFA can be obtained directly from animal foods or synthesized endogenously from 18 carbon precursors via the FADS2 coded enzyme. Vegans rely almost exclusively on endogenous synthesis to generate LCPUFA and we hypothesized that an adaptive genetic polymorphism...
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