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Article

CDKN2A mutations have equivalent prognostic significance to homozygous deletion in IDH-mutant astrocytoma.

Journal of neuropathology and experimental neurology - 20 Sept 2023

Yokoda Raquel T, Cobb William S, Yong Raymund L, Crary John F, Viapiano Mariano S, Walker Jamie M, Umphlett Melissa, Tsankova Nadejda M, Richardson Timothy E

Abstract excerpt

Homozygous deletion of CDKN2A/B is currently considered a molecular signature for grade 4 in IDH-mutant astrocytomas, irrespective of tumor histomorphology. The 2021 WHO Classification of CNS Tumors does not currently include grading recommendations for histologically lower-grade (grade 2-3) IDH-mutant astrocytoma with CDKN2A mutation or other CDKN2A alterations, and little is currently known about the prognostic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37550258
DOI: 10.1093/jnen/nlad063
PMCID: PMC12104504

Genes

CDKN2A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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CDKN2A mutations have equivalent prognostic significance to homozygous deletion in IDH-mutant astrocytoma.PMID 37550258Read ↗

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CDKN2A/B Homozygous Deletions in Astrocytomas: A Literature ReviewSemantic proximity Read ↗

Clinical Utility of Assessing CDKN2A Status in Recurrent AstrocytomasSemantic proximity Read ↗

Homozygous deletion of CDKN2A by fluorescence in situ hybridization is prognostic in grade 4, but not grade 2 or 3, IDH-mutant astrocytomas.Semantic proximity Read ↗

Prognostic value of DNA methylation subclassification, aneuploidy, and CDKN2A/B homozygous deletion in predicting clinical outcome of IDH mutant astrocytomas.Semantic proximity Read ↗

DNA copy number patterns reveal prognostic markers and elucidate mechanisms of evolution in IDH-mutant astrocytoma.Semantic proximity Read ↗

Expanding the molecular grading criteria in IDH-mutant astrocytoma.Semantic proximity Read ↗

Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant GliomaSemantic proximity Read ↗

Molecular and clinical prognostic factors in isocitrate dehydrogenase-mutant astrocytomas: Insights into biomarker-driven stratification.Semantic proximity Read ↗

CDKN2A/B mutations and allele-specific alterations stratify survival outcomes in IDH-mutant astrocytomas.Semantic proximity Read ↗

CDKN2A loss is associated with shortened overall survival in lower-grade (World Health Organization Grades II-III) astrocytomas.Semantic proximity Read ↗

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