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Article

The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.

Leukemia - 1 Sept 2018

Furness Caroline L, Mansur Marcela B, Weston Victoria J, Ermini Luca, van Delft Frederik W, Jenkinson Sarah, Gale Rosemary, Harrison Christine J, Pombo-de-Oliveira Maria S, Sanchez-Martin Marta, Ferrando Adolfo A, Kearns Pamela, Titley Ian, Ford Anthony M, Potter Nicola E, Greaves Mel

Abstract excerpt

Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone contained the STIL-TAL1 fusion and copy number loss of 9p21.3 (CDKN2A/CDKN2B locus), with other copy number alterations including loss of PTEN occurring as secondary subclonal events. In three...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Multiplex Polymerase Chain Reaction

Share to Oncogene Proteins, Fusion

Share to Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Share to PTEN Phosphohydrolase

Share to Single-Cell Analysis

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Source

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Identifiers

PMID: 29556024
DOI: 10.1038/s41375-018-0046-8
PMCID: PMC6127084

Genes

TAL1
STIL
PTEN
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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