Article
Inhibition of PKCδ reduces amyloid-β levels and reverses Alzheimer disease phenotypes.
The Journal of experimental medicine - 4 Jun 2018
Du Ying, Zhao Yingjun, Li Chuan, Zheng Qiuyang, Tian Jing, Li Zhuyi, Huang Timothy Y, Zhang Wei, Xu Huaxi
Abstract excerpt
β-amyloid protein (Aβ) plays a central role in the pathogenesis of Alzheimer disease (AD). Aβ is generated from sequential cleavage of amyloid precursor protein (APP) by β-site APP-cleaving enzyme 1 (BACE1) and the γ-secretase complex. Although activation of some protein kinase C (PKC) isoforms such as PKCα and ε has been shown to regulate nonamyloidogenic pathways and Aβ degradation, it is unclear whether other...
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