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Article

Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.

Human molecular genetics - 15 Jan 2015

Takahashi Hideyuki, Adachi Naoko, Shirafuji Toshihiko, Danno Sally, Ueyama Takehiko, Vendruscolo Michele, Shuvaev Anton N, Sugimoto Takuya, Seki Takahiro, Hamada Daizo, Irie Kazuhiro, Hirai Hirokazu, Sakai Norio, Saito Naoaki

Abstract excerpt

Amyloid assemblies are associated with a wide range of human disorders, including Alzheimer's and Parkinson's diseases. Here, we identify protein kinase C (PKC) γ, a serine/threonine kinase mutated in the neurodegenerative disease spinocerebellar ataxia type 14 (SCA14), as a novel amyloidogenic protein with no previously characterized amyloid-prone domains. We found that overexpression of PKCγ in cultured cells,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25217572
DOI: 10.1093/hmg/ddu472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and characterization of PKCγ, a kinase associated with SCA14, as an amyloidogenic protein.PMID 25217572Read ↗

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