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Article

Bidirectional regulation of Aβ levels by Presenilin 1.

Proceedings of the National Academy of Sciences of the United States of America - 3 Jul 2017

Bustos Victor, Pulina Maria V, Kelahmetoglu Yildiz, Sinha Subhash C, Gorelick Fred S, Flajolet Marc, Greengard Paul

Abstract excerpt

Alzheimer's disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which is generated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of β-secretase, generating the β-C-terminal fragment (βCTF), and then by the Presenilin 1 (PS1) enzyme in the γ-secretase complex, generating Aβ. γ-Secretase is an intramembranous protein complex composed of Aph1,...

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Identifiers

PMID: 28533411
DOI: 10.1073/pnas.1705235114
PMCID: PMC5502639

Genes

APP

Provenance

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Bidirectional regulation of Aβ levels by Presenilin 1.PMID 28533411Read ↗

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