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Article

Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II

8 May 2018

Abstract excerpt

Background DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not stable. We demonstrate that stimulatory signals can change the DNA methylation status around transcription factor binding sites and a transcription start site and activate expression of the aldosterone synthase gene ( CYP 11B2 ). Methods and Results DNA...

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PMID: 29739797
DOI: 10.1161/jaha.117.008281

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