Article
Dynamic CCAAT/enhancer binding protein-associated changes of DNA methylation in the angiotensinogen gene.
Hypertension (Dallas, Tex. : 1979) - 1 Feb 2014
Wang Fen, Demura Masashi, Cheng Yuan, Zhu Aoshuang, Karashima Shigehiro, Yoneda Takashi, Demura Yoshiki, Maeda Yuji, Namiki Mikio, Ono Katsuhiko, Nakamura Yasuhiro, Sasano Hironobu, Akagi Tadayuki, Yamagishi Masakazu, Saijoh Kiyofumi, Takeda Yoshiyu
Abstract excerpt
DNA methylation patterns are maintained in adult somatic cells. Recent findings, however, suggest that all methylation patterns are not preserved. We demonstrate that stimulatory signals can change the DNA methylation status at a CCAAT/enhancer binding protein (CEBP) binding site and a transcription start site and activate expression of the angiotensinogen gene (AGT). A CEBP binding site in the human AGT promoter...
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