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Article

The geometry of partial fitness orders and an efficient method for detecting genetic interactions.

Journal of mathematical biology - 1 Oct 2018

Lienkaemper Caitlin, Lamberti Lisa, Drain James, Beerenwinkel Niko, Gavryushkin Alex

Abstract excerpt

We present an efficient computational approach for detecting genetic interactions from fitness comparison data together with a geometric interpretation using polyhedral cones associated to partial orderings. Genetic interactions are defined by linear forms with integer coefficients in the fitness variables assigned to genotypes. These forms generalize several popular approaches to study interactions, including...

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Identifiers

PMID: 29736875
DOI: 10.1007/s00285-018-1237-7
PMCID: PMC6153669

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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