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Article

Inferring genetic interactions from comparative fitness data.

eLife - 20 Dec 2017

Crona Kristina, Gavryushkin Alex, Greene Devin, Beerenwinkel Niko

Abstract excerpt

Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative tools to make inferences about epistatic gene interactions when the fitness landscape is only incompletely determined due to imprecise measurements or missing observations. We demonstrate that genetic interactions...

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Identifiers

PMID: 29260711
DOI: 10.7554/eLife.28629
PMCID: PMC5737811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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