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Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations.

Journal of theoretical biology - 7 May 2016

Ferretti Luca, Schmiegelt Benjamin, Weinreich Daniel, Yamauchi Atsushi, Kobayashi Yutaka, Tajima Fumio, Achaz Guillaume

Abstract excerpt

Genotypic fitness landscapes are constructed by assessing the fitness of all possible combinations of a given number of mutations. In the last years, several experimental fitness landscapes have been completely resolved. As fitness landscapes are high-dimensional, simple measures of their structure are used as statistics in empirical applications. Epistasis is one of the most relevant features of fitness...

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Epistasis, Genetic
Genotype
Models, Genetic
Mutation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26854875
DOI: 10.1016/j.jtbi.2016.01.037

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