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Article

High-Dimensional Profiling: The Theta Comparative Cell Scoring Method.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Warchal Scott J, Dawson John C, Carragher Neil O

Abstract excerpt

Principal component analysis enables dimensional reduction of multivariate datasets that are typical in high-content screening. A common analysis utilizing principal components is a distance measurement between a perturbagen-such as small-molecule treatment or shRNA knockdown-and a negative control. This method works well to identify active perturbagens, though it cannot discern between distinct phenotypic...

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PMID: 29736718
DOI: 10.1007/978-1-4939-7847-2_13

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