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Article

Multidimensional drug profiling by automated microscopy.

Science (New York, N.Y.) - 12 Nov 2004

Perlman Zachary E, Slack Michael D, Feng Yan, Mitchison Timothy J, Wu Lani F, Altschuler Steven J

Abstract excerpt

We present a method for high-throughput cytological profiling by microscopy. Our system provides quantitative multidimensional measures of individual cell states over wide ranges of perturbations. We profile dose-dependent phenotypic effects of drugs in human cell culture with a titration-invariant similarity score (TISS). This method successfully categorized blinded drugs and suggested targets for drugs of...

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Identifiers

PMID: 15539606
DOI: 10.1126/science.1100709

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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