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Article

A live-cell high-throughput screening assay for identification of fatty acid uptake inhibitors.

Analytical biochemistry - 1 Jan 2005

Li Hong, Black Paul N, DiRusso Concetta C

Abstract excerpt

We developed a live-cell high-throughput assay system using the baker's yeast Saccharomyces cerevisiae to screen for chemical compounds that will inhibit fatty acid uptake. The target for the inhibitors is a mammalian fatty acid transport protein (mmFATP2), which is involved in the fatty acid transport and activation pathway. The mmFATP2 was expressed in a S. cerevisiae mutant strain deficient in Fat1p-dependent...

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PMID: 15582553
DOI: 10.1016/j.ab.2004.09.025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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