Article
Genome-wide transcriptional sequencing identifies novel mutations in metabolic genes in human hepatocellular carcinoma.
Cancer genomics & proteomics - 1 Jan 2000
Meerzaman Daoud M, Yan Chunhua, Chen Qing-Rong, Edmonson Michael N, Schaefer Carl F, Clifford Robert J, Dunn Barbara K, Dong Li, Finney Richard P, Cultraro Constance M, Hu Ying, Yang Zhihui, Nguyen Cu V, Kelley Jenny M, Cai Shuang, Zhang Hongen, Zhang Jinghui, Wilson Rebecca, Messmer Lauren, Chung Young-Hwa, Kim Jeong A, Park Neung Hwa, Lyu Myung-Soo, Song Il Han, Komatsoulis George, Buetow Kenneth H
Abstract excerpt
We report on next-generation transcriptome sequencing results of three human hepatocellular carcinoma tumor/tumor-adjacent pairs. This analysis robustly examined ∼12,000 genes for both expression differences and molecular alterations. We observed 4,513 and 1,182 genes demonstrating 2-fold or greater increase or decrease in expression relative to their normal, respectively. Network analysis of expression data...
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