Article

PD1 is transcriptionally regulated by LEF1 in mature T cells

2023-03-02

Abstract excerpt

Programmed cell death 1 (PD1) plays a vital role in cancer immune evasion. So monoclonal antibodies targeting PD-1 to boost the immune system are being developed for the treatment of cancer. But the effect of PD1/PD-L1 blocking antibody only works in a subset of patients or some tumors. It is well established that PD-1 can affect the positive selection of T cells. Mice lacking PD1 or PD-L1 had more DP T cells in t...

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Literature Corpus work: 94101255-c69f-5f45-a8bc-a5dda52dc964
DOI: 10.1101/2023.03.01.530714

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