Article
Chinese and Europeans with acute myeloid leukemia have discordant mutation topographies.
Leukemia research - 1 Jul 2018
Zhang Min, Yin Jiawei, He Qinghua, Zhang Fan, Huang Hongyu, Wu Biao, Wang Xuedong, Liu Hong, Yin Hongchao, Zeng Yan, Gale Robert Peter, Wu Depei, Yin Bin
Abstract excerpt
Although the topography of mutations in persons of predominately European-descent with acute myeloid leukemia (AML) is well-described this is less so in Asians. We studied AML-related mutations in 289 consecutive Chinese (mostly Han) with newly-diagnosed de novo AML. Full-length coding sequence of NPM1 and CEBPA, IDH1 and IDH2 hotspot mutations and WT1 mutations in exons 7 and 9 were analyzed by PCR as were...
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