Article

Epigenenomic and transcriptomic characterization of <i>NPM1</i> -mutated CN-AML subtypes

2024-05-10

Abstract excerpt

<h4>ABSTRACT</h4> Cytogenetic normal AML with NPM1 mutations forms a distinct AML entity, associated with an intermediate prognosis and a heterogeneous response to treatment. We previously described an epigenetic biomarker, defined by the level of H3K27me3 on 70kb of the HIST1 cluster in patient blast DNA. This epigenetic mark separates cytogenetically normal NPM1 mut AML into two groups of patients differing...

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Literature Corpus work: 93fea0e7-6f0e-5418-bfb1-15cdb40105c4
DOI: 10.1101/2024.05.07.592738

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