Article
Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.
Cell death & disease - 1 May 2018
Li Ming, Wu Xiao-Mo, Gao Ju, Yang Fen, Zhang Cui-Lin, Ke Kun, Wang Ying-Chao, Zheng You-Shi, Yao Jian-Feng, Guan Ying-Ying, Chen Xuan, Chen Juan, Liu Xiao-Long, Yang Xiao-Yu
Abstract excerpt
Caspase-8 activation initiates apoptotic signaling cascades, and certain mutations in procasepase-8 have been reported to be associated with the progression and prognosis of different types of tumors. In this study, we have identified four novel mutations, which are highly correlated with chemotherapy resistance and poor prognosis of acute myeloid leukemia (AML) patients, within the P10 subunit of procaspase-8....
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