Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization.

Biochemical and biophysical research communications - 1 Jan 2018

Li Ming, Yao Jianfeng, Zhang Xiangxi, Chen Xuan, Chen Juan, Guan Yingying, Yang Xiaoyu

Abstract excerpt

INTRODUCTION: Certain procaspase-8 mutations are reported to be associated with the progression and prognosis of multiple tumors. However, it remains unclear whether the poor chemotherapy response and frequent relapse after complete remission of patients with acute myeloid leukemia (AML) is also related to procaspase-8 abnormalities. METHODS: Polymerase chain reaction (PCR) amplification and Sanger sequencing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Caspase 8

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dimerization

Share to Drug Resistance, Neoplasm

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to Leukemia, Myeloid, Acute

Share to Tumor Cells, Cultured

Source

Identifiers

PMID: 29191655
DOI: 10.1016/j.bbrc.2017.11.168

Genes

CASP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Q482H mutation of procaspase-8 in acute myeloid leukemia abolishes caspase-8-mediated apoptosis by impairing procaspase-8 dimerization.PMID 29191655Read ↗

Mutations in the P10 region of procaspase-8 lead to chemotherapy resistance in acute myeloid leukemia by impairing procaspase-8 dimerization.Semantic proximity Read ↗

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in GlioblastomaSemantic proximity Read ↗

A double tyrosine phosphorylation of P68 RNA helicase confers resistance to TRAIL-induced apoptosis.Semantic proximity Read ↗

Caspase-8 regulation of TRAIL-mediated cell death.Semantic proximity Read ↗

PARP-1 improves leukemia outcomes by inducing parthanatos during chemotherapySemantic proximity Read ↗

Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis.Semantic proximity Read ↗

Multiparametric analysis of apoptotic and multi-drug resistance phenotypes according to the blast cell maturation stage in elderly patients with acute myeloid leukemia.Semantic proximity Read ↗

Association of caspase9 promoter polymorphisms with the susceptibility of AML in south Indian subjects.Semantic proximity Read ↗

Caspase-8 mutations in head and neck cancer confer resistance to death receptor-mediated apoptosis and enhance migration, invasion, and tumor growth.Semantic proximity Read ↗

Modulation of apoptosis by procaspase-2 short isoform: selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization.Semantic proximity Read ↗

Single nucleotide polymorphisms in apoptosis pathway are associated with response to imatinib therapy in chronic myeloid leukemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.