Article
Redesigning the procaspase-8 dimer interface for improved dimerization.
Protein science : a publication of the Protein Society - 1 Apr 2014
Ma Chunxiao, MacKenzie Sarah H, Clark A Clay
Abstract excerpt
Caspase-8 is a cysteine directed aspartate-specific protease that is activated at the cytosolic face of the cell membrane upon receptor ligation. A key step in the activation of caspase-8 depends on adaptor-induced dimerization of procaspase-8 monomers. Dimerization is followed by limited autoproteolysis within the intersubunit linker (IL), which separates the large and small subunits of the catalytic domain....
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