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Article

Caspase-8: A Novel Target to Overcome Resistance to Chemotherapy in Glioblastoma

29 Nov 2018

Abstract excerpt

Caspase-8 was originally identified as a central player of programmed cell death triggered by death receptor stimulation. In that context, its activity is tightly regulated through several mechanisms, with the best established being the expression of FLICE-like inhibitory protein (FLIP) family proteins and the Src-dependent phosphorylation of Caspase-8 on Tyr380. Loss of apoptotic signaling is a hallmark of...

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PMID: 30501030
DOI: 10.3390/ijms19123798

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