Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.

PloS one - 1 Jan 2018

Barrera Julio, Subramanian Shobana, Chiba-Falek Ornit

Abstract excerpt

Peroxisome proliferator-activated receptor-γ (PPARγ), is a transcription factor that governs pathways, such as lipid metabolism and immune response, that have been implicated in the etiology of LOAD. Previously, we established HepG2-derived cell-lines with stable knockdown of PPARγ gene, and showed an increase in mRNA levels of genes mapped in the APOE linkage disequilibrium (LD) region on chromosome 19q13.32,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to ATP-Binding Cassette Transporters
Share to Desmoglein 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Focal Adhesion Kinase 2

Share to Gene Knockdown Techniques

Share to Hep G2 Cells

Share to PPAR gamma

Share to RNA, Small Interfering

Source

Open in PubMed Open full text

Identifiers

PMID: 29723294
DOI: 10.1371/journal.pone.0196943
PMCID: PMC5933777

Genes

APOE
ABCA7
CASS4
CELF1
DSG2
ZCWPW1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.PMID 29723294Read ↗

Genome-wide analysis of LXRα activation reveals new transcriptional networks in human atherosclerotic foam cells.Semantic proximity Read ↗

Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.Semantic proximity Read ↗

Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARgamma as susceptibility loci.Semantic proximity Read ↗

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.Semantic proximity Read ↗

Gene- gene interaction between CYP2J2 and PPAR -γ gene on late-onset Alzheimer's disease in the eastern Chinese Han population.Semantic proximity Read ↗

Gene- Gene Interaction between PPARG and APOE Gene on Late-Onset Alzheimer's Disease: A Case- Control Study in Chinese Han Population.Semantic proximity Read ↗

Identification of functional non-coding variants affecting Alzheimer’s disease risk by Massively Parallel Reporter AssaySemantic proximity Read ↗

Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset Alzheimer's disease in the Finnish population.Semantic proximity Read ↗

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s diseaseSemantic proximity Read ↗

Improved insulin sensitivity after treatment with PPARγ and PPARα ligands is mediated by genetically modulated transcripts.Semantic proximity Read ↗

The effects of PPARγ on the regulation of the TOMM40 - APOE - C1 genes clusterSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.