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Article

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.

Neurobiology of aging - 1 Mar 2011

Combarros Onofre, Rodríguez-Rodríguez Eloy, Mateo Ignacio, Vázquez-Higuera José Luis, Infante Jon, Berciano José, Sánchez-Juan Pascual

Abstract excerpt

The peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-inducible transcription factor that suppresses microglial inflammatory responses and inhibits amyloid beta (Aβ) production through promoting cholesterol efflux from glial cells. PPAR-γ agonists have been advanced as a new disea...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19660836
DOI: 10.1016/j.neurobiolaging.2009.07.004

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19660836-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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