Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.

Current Alzheimer research - 1 Oct 2009

Kalinin Sergey, Richardson Jill C, Feinstein Douglas L

Abstract excerpt

Agonists of the peroxisome proliferator activated receptor gamma (PPARgamma) have been shown to reduce inflammatory responses in several animal models of neurological diseases and conditions and to reduce amyloid burden in transgenic mice expressing mutant forms of human amyloid precursor protein. However, the effects of activating the related receptor PPARdelta (PPARdelta), which is expressed at higher levels in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalitis

Share to Neprilysin

Share to Plaque, Amyloid

Share to PPAR delta

Share to Presenilin-1

Share to Thiazoles

Source

Identifiers

PMID: 19874267
DOI: 10.2174/156720509789207949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A PPARdelta agonist reduces amyloid burden and brain inflammation in a transgenic mouse model of Alzheimer's disease.PMID 19874267Read ↗

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptorsSemantic proximity Read ↗

Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology.Semantic proximity Read ↗

Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine modelSemantic proximity Read ↗

PPAR-α agonist regulates amyloid-β generation via inhibiting BACE-1 activity in human neuroblastoma SH-SY5Y cells transfected with APPswe geneSemantic proximity Read ↗

Effects of the PPARgamma activator pioglitazone on p38 MAP kinase and IkappaBalpha in the spinal cord of a transgenic mouse model of amyotrophic lateral sclerosis.Semantic proximity Read ↗

Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.Semantic proximity Read ↗

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.Semantic proximity Read ↗

Rethinking Alzheimer’s: Harnessing Cannabidiol to Modulate IDO and cGAS Pathways for Neuroinflammation ControlSemantic proximity Read ↗

Interferon-γ and Tumor Necrosis Factor-α Regulate Amyloid-β Plaque Deposition and β-Secretase Expression in Swedish Mutant APP Transgenic MiceSemantic proximity Read ↗

Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.Semantic proximity Read ↗

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease modelSemantic proximity Read ↗

PPAR-α agonist pirinixic acid alleviates periodontitis-induced AD-like pathology via suppression of the IRF7-IFN-β-IFITM3 axis in glial cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.